The Neurobiology of SchizophreniaTed Abel, Thomas Nickl-Jockschat The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance.
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Contents
| 15 | |
III The Neurochemical Basis of Schizophrenia | 107 |
IV The Biochemical Basis of Schizophrenia | 165 |
V The ElectroPhysiological Basis of Schizophrenia | 211 |
VI The Structure and Function of Neural Circuits in
Schizophrenia | 261 |
VII Modeling Schizophrenia in Animals | 351 |
| 419 | |
| 433 | |
Back Cover | 449 |
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abnormalities Acad activity alterations analysis animal models antipsychotic associated auditory behavioral Biol biomarkers bipolar disorder Brain Atlas brain regions cells clinical CNVs cognitive complex connectivity connectome correlated cortical D2 receptor decreased deficits deletion dendritic spines DISC1 disease DNA methylation dopamine dopaminergic drug dysfunction effects endophenotypes epigenetic fMRI frontal functional GABAA receptors gamma oscillations gene expression genetic genome genome-wide glutamate GWAS hallucinations healthy controls Heuvel hippocampus human brain imaging impaired increased inhibition interactions interneurons mechanisms memory meta-analysis mice modulation molecular Mouse Brain mouse models mutations neural Neuregulin neuroimaging neurons neuropsychiatric Neuropsychopharmacology Neurosci NMDA receptor pathways patients with schizophrenia phenotypes phrenia postsynaptic potential prefrontal cortex prepulse inhibition protein proteome Psychiatry psychosis reduced Retrieved risk role schizo Schizophr schizophrenia schizophrenia patients sensory signaling SNPs spatial specific Sporns striatal striatum structural studies subunit symptoms synaptic temporal tion variants