Actinomycin: Nature, Formation, and Activities

actino actinomycin activity agent amino acid animals anti antibiotic antibioticus antibody antibody synthesis antigen Biochem Biol Biophys biosynthesis Brockmann C₁ Cancer carcinoma cells cellular chemical chemotherapy chick chlorambucil choriocarcinoma chromophore clinical concentrations D-alloisoleucine D-Val D-Val D-valine differentiation DMBA dose of actinomycin double-stranded drug effect of actinomycin embryos enzyme Exptl formation gene action growth Hackmann hydroxyproline immune immunological incorporation infection inhibition inhibitors intravenous isolated Katz L-Meval L-Meval L-Thr L-Thr L-Thr liver messenger RNA metabolic metastases methotrexate mice molecule Mouse mRNA mycin N.Y. Acad Natl normal nucleic acid observed organism patients peptide phenoxazinone precursor Proc production proline protein synthesis puromycin radiotherapy rats reaction Reich replication response ribonucleic acid RNA synthesis Rous sarcoma virus Sar Sar Sar sarcosine Schmidt-Kastner sensitive specific spleen Streptomyces studies therapy tion titer toxic treatment tryptophan tumor Valine Valine N-Methylvaline Sarcosine viral RNA Virology virus viruses vitro Waksman Wilms µg/kg µg/ml