MyelopeptidesMyelopeptides are a new class of endogenous bioregulatory peptides. Each has its own definite immunoregulatory activity and differs in their final effects and mechanisms of action. Myelopeptides act as immunocorrectors and thus prevent the development of immunodeficiency states. They have an antitumor effect which contributes to the retention of active immune defense in the tumor-bearing body. The ability of myelopeptides to induce terminal cell differentiation in hemopoietic disorders (in particular, in leukemia) is demonstrated. The protective effect of a single myelopeptide in bacterial contagion of animals, which is due to the stimulation of macrophage phagocytosis, is established. In this book, the concept of the general biological value of cytokines, including peptide endogenous regulators, is discussed. Myelopeptides are promising in the development of a new generation of medicinal preparations because of their endogenous origin, low molecular weight, directed action and absence of side effects.This book is intended for those interested in medical and biological problems: lecturers and students in medical and biological universities, scientists and researchers from medical and biological laboratories, and other professionals involved in medical and biological research. |
Contents
New immunoregulatory bone marrow peptides | 1 |
A group of bone marrow bioregulatory | 15 |
Myelopeptides and human immune reactions | 47 |
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Common terms and phrases
activity of MPs acute lymphoblastic leukemia AFC number amino acid animals antibody formation antibody production antibody-stimulating antigen antitumor effect biological activities bone marrow cells CD4+ cell culture cell differentiation cisplatinum concentration cultivation decrease dose effect of MPs endogenous experimental FITC-labeled fraction functional activity g/mouse healthy donors hemoglobin hemopoiesis Ig synthesis immune lymph node immune response immune system immunocorrecting immunodeficiency immunoregulatory increase incubated individual MPs induced influence of MPs inhibition injection of MPs isolated lymph node cells macrophage marrow cell culture mature antibody producers mg/kg mice Mikhailova mitogen mixed culture mixture of MPs mouse spleen cells myeloblastic Myelopeptides Myelopid treatment node cells obtained normal number of AFC peptides peripheral blood cells Petrov phagocytosis precursor proliferation proliferative response protein synthesis receptors response to SRBC spleen Stepanenko Stimulation coefficient stimulation of antibody supernatant suppressors Table therapy thymus tumor tumor cells vitro µg/ml