Abstract
Unitary responses in the hypothalamic nuclei to stimulation of the frontobasal zones of the cortex (proreal, orbito-insular, and basal temporal regions) were studied. Cortico-thalamic connections were found to possess definite topical organization: the orbito-frontal zones of the cortex have a more marked effect on unit activity of the hypothalamic nuclei than the basal temporal cortex. Antidromic activation, during stimulation of a particular region of the cortex, of neurons excited orthodromically by stimulation of another cortical structure, enables a number of neuronal circuits functioning within the forebrain to be distinguished. The first circuit includes the orbital gyrus, preoptic zone, and proreal gyrus. The second circuit has the same cortical components as the first, but its relay in the hypothalamus takes place in the region of the mamillary bodies. The third circuit is represented by the basal temporal cortex, lateral hypothalamus, and prefrontal cortex.
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Literature cited
O. G. Baklavadzhyan, A. G. Arkelyan, and L. A. Balasonyan, "Analysis of evoked discharges in hypothalamic neurons to somatosensory, acoustic, and photic stimulation," Neirofiziologiya,3, 592 (1971).
V. G. Zilov, "Interaction between cortical and reticular influences on neurons of the lateral hypothalamus," Fiziol. Zh. SSSR,55, 1436 (1969).
N. I. Dubrovina and R. Yu. Il'yuchenok, "Comparative effects of amygdala and central gray matter of the midbrain on lateral hypothalamic unit activity," Neirofiziologiya,9, 25 (1977).
V. N. Kazakov, "Functional organization and connections of the orbitofrontal cortex," Author's Abstract of Doctoral Dissertation, Odessa (1971), 24 pp.
V. N. Kazakov, P. Ya. Kravtsov, and V. N. Rassokhin, "Electrophysiological studies of cortico-hypothalamic relations in the cat," Neirofiziologiya,8, 358 (1976).
G. I. Kiknadze, "Structural organization and connections of the proreal gyrus of the cerebral cortex," Author's abstract of Candidate's Dissertation, Tbilisi, (1969), 17 pp.
P. Ya. Kravtsov, "The role of corticofugal influence in unit activity of hypothalamic structures," Authors' Abstract of Candidate's Dissertation, Donetsk (1976), 21 pp.
A. I. L'vovich, "Cortico-mammillary pathways of the brain," Arkh. Anat. Gistol. Émbriol.,61, 64 (1971).
F. N. Serkov, E. Sh. Yanovskii, and A. I. Tal'nov, "Functional properties distinguishing individual auditory cortical neurons," Neirofiziologiya,5, 236 (1973).
K. V. Sudakov, "A study of ascending activating influences on the cortex during starvation and by local polarization of the hypothalamus," Fiziol. Zh. SSSR,49, 901 (1963).
W. R. Adey and M. Meyer, "Hippocampal and hypothalamic connections of the temporal lobe in the monkey," Brain,75, 358 (1952).
P. Gloor, J. T. Murphy, and J. J. Dreifuss, "Anatomical and physiological characteristics of the two amygdaloid projection systems to the ventromedial hypothalamus," in: Limbic Mechanisms and Autonomic Function, Thomas, Springfield, Ill. (1972).
M. Ito, "Activation and inhibition of the lateral hypothalamic neurons elicited by medial forebrain bundle stimulation," J. Physiol. (London),254, 109 (1976).
H. Hasper and C. Ajmone-Marsan, A Stereotaxic Atlas of the Diencephalon of the Cat, National Research Council of Canada, Ottawa (1954).
K. Koizumi, T. Ishikawa, and M. C. Brooks, "Control of activity of neurons in the supraoptic nucleus," J. Neurophysiol.,5, 875 (1964).
J. Marsala, "Efferente frontostriatische, frontohypothalamische und frontothalamische Bahren des Gehirns der Katze," Biol. Prace,11, No. 7, 95 (1965).
J. T. Murphy, J. J. Dreifuss, and P. Gloor, "Topographical differences in the responses of single hypothalamic neurons to limbic stimulation," Am. J. Physiol.,214, 1443 (1968).
O. Millhouse, "A Golgi study of the descending medial forebrain bundle," Brain Res.,15, 341 (1969).
J. T. Murphy and L. P. Renaud, "Synaptic events produced by activation of the amygdalofugal pathways to the hypothalamic ventromedial nucleus," in: Limbic System Mechanisms and Autonomic Function, C. C. Thomas, Springfield, Illinois (1972), pp. 78–82.
W. J. H. Nauta, "Some efferent connections of the prefrontal cortex in the monkey," in: The Frontal Cortex and Behavior, McGraw-Hill, New York (1964), pp. 397–409.
W. J. H. Nauta, "Neural associations of the frontal cortex," Acta Neurobiol. Exp.,2, 125 (1972).
C. G. Phillips, "Actions of antidromic pyramidal volleys on single Betz cells in the cat," Quart. J. Exp. Physiol.,44, 1 (1959).
M. Rasminsky, A. J. Mauro, and D. Albe-Fessard, "Projections of medial thalamic nuclei to putamen and cerebral frontal cortex in the cat," Brain Res.,61, 69 (1973).
E. Sachs, S. Brendier, and L. Fulton, "The orbital gyri," Brain,72, 227 (1949).
M. E. Scheibel and A. B. Scheibel, "The organization of the nucleus reticularis thalami: a Golgi study," Brain Res.,1, 43 (1966).
A. Ward and W. S. McCulloch, "The projection of the frontal lobe on the hypothalamus," J. Neurophysiol.,10, 309 (1947).
F. Valverde, "Studies on the forebrain of the mouse: Golgi observation," J. Anat.,97, 157 (1963).
D. G. Whitlock and W. J. Nauta, "Subcortical projections from temporal neocortex inMacaca mulatta," J. Comp. Neurol.,106, 183 (1956).
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M. Gor'kii Donetsk Medical Institute. Translated from Neirofiziologiya, Vol. 10, No. 1, pp. 44–53, January–February, 1978.
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Kazakov, V.N., Kravtsov, P.Y. Unitary responses of the hypothalamic nuclei to stimulation of the frontobasal neocortex. Neurophysiology 10, 33–40 (1978). https://doi.org/10.1007/BF01063345
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DOI: https://doi.org/10.1007/BF01063345