Poisons of Plant OriginIn Volume 1 of this series, attention was focused on neuropoisons of animal origin. In the present volume, attention has been shifted to poisons of plant origin. In both cases, we have attempted to identify those poisons for which there is a large measure of clinical or research interest. Our efforts in compiling the series have been aided by three groups of individuals. First, we are grateful to the investigators who contributed chapters. Their labors are the substance of this two-volume work. Second, we are pleased to acknowledge the support of Mr. Seymour Weingarten and Plenum Press in our project. And third, we have been immeasurably aided by our assistants, Mrs. Ruby Hough in New York City and Mrs. Helena Walsh in Canberra. To all these persons, we are indebted. Dr. Lance L. Simpson Dr. David R. Curtis New York City Canberra vii Contents Chapter 1 Reserpine 1 by Theodore A. Slot kin I. Introduction .......................................... . |
Contents
| 1 | |
| 7 | |
Effects on Biogenic Amine Uptake Retention | 19 |
G Mechanism of Action of Reserpine | 29 |
Biochemical Effects | 35 |
Pharmacological Effects | 41 |
Clinical Uses and Toxicity | 45 |
Chapter 2 | 61 |
Chapter 4 | 157 |
Toxicology | 166 |
References | 175 |
Basic Amino Acids | 189 |
Chapter 6 | 193 |
Conclusions | 197 |
Convulsant Alkaloids | 207 |
Bicuculline and Related Substances | 219 |
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Common terms and phrases
acetylcholine Acta action of nicotine activity administration adrenal medulla adrenergic agents alkaloids amines amino acids antagonism antagonist atropine bicuculline binding Biochem Biol blockade blocked Brain Res Brit Carlsson catecholamines central nervous system cholamines cholinergic receptors compounds concentrations convulsant cortical curare curare-like Curtis decamethonium decrease denervated depletion depolarization depression dihydroergotamine dopamine doses drugs effects of reserpine end-plate enzyme epinephrine ergot ergot derivatives ergotamine excitation excitatory Exptl fects fibers frog function GABA ganglia ganglion glutamic acid glycine increased inhibition inhibitory injection interaction intraperitoneal intravenous isolated Johnston Kirshner Langley Lathyrus mechanism membrane metabolism methysergide mg/kg mmol/kg molecule monoamine oxidase muscarinic muscimol Nature Lond nerve terminals neurons nicotine NorE norepinephrine ODAP peripheral Pharmacol pharmacological Physiol picrotoxin postsynaptic potential presynaptic produced reflexes release Renshaw cells reserpine response serotonin skeletal muscle Slotkin spinal cord stimulation storage vesicles strychnine studies sympathetic synaptic synthesis Therap tissue toxic transmission transmitter tubocurarine