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Facilitation of reactions of cortical neurons to cortical and peripheral stimulation after tetanization of the brain surface

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Abstract

The electrical activity of neurons of the sensomotor cortex of an unanesthetized rabbit was investigated. Conditioning tetanization of the cortex was carried out through surface electrodes located close to the site of the lead. Test stimuli were supplied through electrodes 2.5–12 mm more caudally on the cortical surface. In addition, peripheral test stimuli were applied. Impulse reactions to previously ineffective stimuli develop after conditioning tetanization and prolonged (up to 1 min) intensification of exciting postsynaptic potentials (EPSP) to cortical and peripheral test stimuli is observed. Facilitation of the reactions is especially clear during tetanization superthreshold for evoking epileptiform afterdischarges. It continued after the conclusion of these discharges and could also be observed during tetanization subthreshold for evoking afterdischarges. The time course of the facilitation was similar to the time course of the post-tetanic intensification of reactions of single stimuli applied with the electrodes used for tetanization. An analysis of the changes in intracellular activity makes it possible to assume that the mechanism of post-tetanic potentiation (PTP) lies at the basis of the described facilitation, which is considered as the "cellular analog" of the dominant focus which develops as a result of tetanization of the cortical surface.

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  1. L. L. Voronin
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Institute of the Brain, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 3, No. 1, pp. 3–12, January–February, 1971.

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Voronin, L.L. Facilitation of reactions of cortical neurons to cortical and peripheral stimulation after tetanization of the brain surface. Neurophysiology 3, 1–8 (1971). https://doi.org/10.1007/BF01065584

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  • DOI: https://doi.org/10.1007/BF01065584

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