Cognitive Impairment in Schizophrenia: Characteristics, Assessment and TreatmentPhilip D. Harvey Although the precise mechanisms and pathways of schizophrenia remain something of a mystery, there is little dispute that cognitive deficits present as some of the clearest and most debilitating symptoms of the disease. This book describes the characteristics of cognitive deficits in schizophrenia, functional implications, the course of impairments, the genetic and biological contributions and reviews management options, including neuropsychological, psychological and pharmacological techniques. Chapters are written by leading experts in the field, in an accessible and highly informative style, ensuring the content is clinically relevant. State-of-the-art information about new developments in the treatment of related features of the illness, such as disability, is provided. The wide ranging focus of this volume will appeal to clinicians and academic researchers working with patients impaired by severe mental illness. |
Contents
Cognition as a central illness feature in schizophrenia | 1 |
The multifaceted global cognitive impairment profile in schizophrenia | 24 |
Comparative impairments across schizophrenia and bipolar disorder | 50 |
Cognitive impairment and symptom dimensions in psychosis | 69 |
Neurocognition and functional outcome in schizophrenia filling in the gaps | 85 |
Cognition and work functioning in schizophrenia | 98 |
Cognition and functional status in adult and older patients with schizophrenia | 110 |
Social cognition and its relationship to neurocognition | 126 |
Genetic influences on cognition in schizophrenia | 161 |
Neurobiological determinants of cognition | 176 |
Translational cognitive neuroscience of schizophrenia bridging neurocognitive and computational approaches toward understanding cognitive deficits | 193 |
Assessment of cognition in schizophrenia treatment studies | 231 |
Performancebased measures of functioning in schizophrenia | 247 |
Pharmacological approaches to cognitive enhancement | 266 |
Computerized cognitive training in schizophrenia current knowledge and future directions | 284 |
| 316 | |
Cognitive functioning and awareness of illness in schizophrenia a review and metaanalysis | 142 |
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abnormalities activity American Journal antipsychotic Archives assessment associated auditory Barch battery behavioral benefit Biological Psychiatry bipolar disorder brain clinical trials cognition in schizophrenia cognitive ability cognitive deficits cognitive domains cognitive enhancement cognitive functioning cognitive impairment cognitive neuroscience cognitive performance cognitive remediation cognitive training computerized correlations cortical deficits deficits in schizophrenia difficulty DLPFC dysfunction effect sizes encoding episodic memory evidence executive functions findings first first-episode functional outcome functioning in schizophrenia genetic Harvey healthy controls identified impairment in schizophrenia individuals with schizophrenia influence insight Journal of Psychiatry Keefe ketamine McGurk medications meta-analysis mismatch negativity negative symptoms neural neurocognition neuropsychological neuropsychological test PANSS patients with schizophrenia performance-based measures prefrontal cortex processing speed Psychiatry Research Psychological psychosis psychotic reflect rehabilitation Reichenberg relationship relative sample Schizophrenia Bulletin schizophrenia patients Schizophrenia Research scores significant skills social cognition specific studies symptom dimensions tasks theory of mind treatment verbal memory visual WCST