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Contemporary Issues in Modeling Psychopathology pp 113–141Cite as

Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition

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Part of the book series: Neurobiological Foundation of Aberrant Behaviors ((NFAB,volume 1))

Abstract

“I can’t get the memories out of my mind! The images come flooding back in vivid detail, triggered by the most inconsequential things, like a door slamming or the smell of stir-fried pork. Last night, I went to bed, was having a good sleep for a change. Then in the early morning a storm-front passed through and there was a bolt of crackling thunder. I awoke instantly, frozen in fear. I am right back in Viet Nam, in the middle of the monsoon season at my guard post. I am sure I’ll get hit in the next volley and convinced I will die. My hands are freezing, yet sweat pours from my entire body. I feel each hair on the back of my neck standing on end. I can’t catch my breath and my heart is pounding. I smell a damp sulfur smell. Suddenly I see what’s left of my buddy Troy, his head on a bamboo platter, sent back to our camp by the Viet Cong. Propaganda messages are stuffed between his clenched teeth. The next bolt of lightning and clap of thunder makes me jump so much that I fall to the floor..... ” (Paraphrased from a war veteran’s conversations with Dr. R. L. Gelman, Dept. of Psychiatry, Yale University School of Medicine).

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References

  • Aggleton, J.P. (1992) The amygdala. Neurochemical aspects of emotion, memory, and mental dysfunction. New York: John Wiley-Liss and Sons.

    Google Scholar 

  • Annau, Z. and Kamin, L.J. (1961) The conditioned emotional response as a function of US intensity. Journal of Comparative and Physiological Psychology 54: 428–432.

    Article  PubMed  CAS  Google Scholar 

  • Baker, J.D. and Azorlosa, J.L. (1996) The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning. Behav Neurosci 110: 618–620.

    Article  PubMed  CAS  Google Scholar 

  • Bandler, R. and Shipley, M.T. (1994) Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? TINS 17: 379–389.

    PubMed  CAS  Google Scholar 

  • Berger, T.W., Weiker,t C.L., Basset, J.L., On, W.B. (1986) Lesions of the retrosplinal cortex produce deficits in reversal learning of the rabbit nictitating membrane response: implications for potential interactions between hippocampal and cerebellar brain systems. Behav Neurosci 100: 802–809.

    CAS  Google Scholar 

  • Bolles, R.C. and Fanselow, M.S. (1980) A perceptual-defensive-recuperative model of fear and pain. The behavioral and brain sciences 3: 281–323.

    Google Scholar 

  • Borowski, T.B. and Kokkinides, L. (1998) The effects of cocaine, amphetamine, and the dopamine D1 receptor agonist SKF 38393 on fear extinction as measured with potentiated startle: Implications for psychomotor stimulant psychosis. Behav Neurosci 112: 952–965.

    Google Scholar 

  • Bouton, M.D. and Bolles, R.C. (1979a) Role of contextual stimuli in reinstatement of extinguished fear. J Exp Psychol: Animal Behav Process 5: 368–378.

    Google Scholar 

  • Bouton, M.E. (1993) Context, time and memory retrieval in the interference paradigms of Pavlovian conditioning. Psychological Bulletin 114: 80–99.

    Article  PubMed  CAS  Google Scholar 

  • Bouton, M.E. and Bolles, R.C. (1979b) Contextual control of the extinction of conditioned fear. Learn and Motiv 10: 455–466.

    Google Scholar 

  • Bouton, M.E. and Bolles, R.C. (1985) Context, event-memories, and extinction. Hillsdale, NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • Bouton, M.E. and Brooks, D.C. (1993) Time and context effects on performance in a Pavlovian discrimination reversal. Behav Neurosci 19: 165–179.

    Google Scholar 

  • Bouton, M.E., Kenney, F.A., Rosengard, C. (1990) State-dependent fear extinction with two benzodiazepine tranquilizers. Behav Neurosci 104: 44–55.

    Article  PubMed  CAS  Google Scholar 

  • Bouton, M.E. and King, D.A. (1983) Contextual control of conditioned fear: tests for the associative value of the context. J Exp Psychol: Animal Behav Process 9: 248–256.

    Google Scholar 

  • Bouton, M.E. and King, D.A. (1986) Effect of context with mixed histories of reinforcement and nonreinforcement. J Exp Psychol: Animal Behav Process 12: 4–15.

    Google Scholar 

  • Bouton, M.E. and Nelson, J.B. (1994) Context specificity of target versus feature inhibition in a featurenegative discrimination. J Exp Psychol: Animal Behav Process 20: 51–65.

    Google Scholar 

  • Bouton, M.E. and Swartzentruber, D. (1991) Sources of relapse after extinction in Pavlovian instrumental learning. Clinical Psychological Review 11: 123–140.

    Article  Google Scholar 

  • Buchanan, S.L. and Powell, D.A. (1980) Divergencies in Pavlovian conditioned heart rate and eyeblink responses produced by hippocampectomy in the rabbit ( Oryctolagus cuniculus ). Behav Neural Biol 30: 20–38.

    Google Scholar 

  • Burns, L.H., Everitt, B.J., Kelly, A.E., Robbins, T.W. (1994) Glutamate-dopamine interactions in the ventral striatum: role in locomotor activity and responding with conditioned reinforcement. Psychopharmacology 115: 516–528.

    Article  PubMed  CAS  Google Scholar 

  • Campeau, S. and Davis, M. (1992b) Involvement of the lateral amygdala and perirhinal cortex in fear potentiated startle to acoustic and visual conditioned stimuli. Soc Neurosci Abst 18: 1562.

    Google Scholar 

  • Campeau, S. and Davis, M. (1995) Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 15: 2312–2327.

    PubMed  CAS  Google Scholar 

  • Campeau, S,. Falls, W.A., Cullinan, W.E., Helmreich, D.L., Davis, M,. and Watson, S.J. (1997) Elicitation and reduction of fear: behavioral and neuroendocrine indices and brain induction of the immediate-early gene c-fos. Neuroscience 78: 1087–1104.

    Article  Google Scholar 

  • Campeau, S., Miserendino, M.J.D., Davis, M. (1992) Intra-amygdala infusion of the N-methyl-DAspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav Neurosci 106: 569–574.

    Article  PubMed  CAS  Google Scholar 

  • Coco, M.L., Kuhn, C.M., Ely, T.D., Kilts, C.D. (1992) Selective activation of mesoamygdaloïd dopamine neurons by conditioned stress: attenuation by diazepam. Brain Res 590: 39–47.

    Article  PubMed  CAS  Google Scholar 

  • Cox, J. and Westbrook, R.F. (1994) The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesia responses in the rat. Quarterly Journal of Experimental Psychology 47B: 187–210.

    PubMed  CAS  Google Scholar 

  • Davis, M,. Rainnie, D., Cassell, M. (1994) Neurotransmission in the rat amygdala related to fear and anxiety. Trends in Neuroscience 17: 208–214.

    Article  Google Scholar 

  • DeOca, B.M., DeCola, J.P., Maren, S., Fanselow, M.S. (1998) Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses. The Journal of Neuroscience: 3426–3432.

    Google Scholar 

  • Deutch, A.Y., Clark, W.A., Roth, R.H. (1990) Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Brain Res 521: 311–315.

    Article  PubMed  CAS  Google Scholar 

  • Dickinson, A. and Pearce, J.M. (1977) Inhibitory interactions between appetitive and aversive stimuli. Psychologcal Bulletin 84: 690–711.

    Article  Google Scholar 

  • Douglas, R.J. (1972) Inhibition and learning. Pavlovian conditioning in the brain. London: Academic Press.

    Google Scholar 

  • Estes, W. (1955) Statistical theory of spontaneous recovery and regression. Psychology Review 62: 145154.

    Google Scholar 

  • Falls, W.A., Bakken, S., and Heldt, S.A. (1997) Lesions of the perirhinal cortex block conditioned excitation but not conditioned inhibition of fear. Behav Neurosci 111: 476–486.

    Article  PubMed  CAS  Google Scholar 

  • Falls, A. and Davis, M. (1995a) Behavioral and physiological analysis of fear inhibition. In: M. J. Friedman, Charney D. S. and Deutch A. Y., eds. Neurobiological and clinical consequences of stress: From normal adaptation to PTSD. Philadelphia: Lippincott-Raven Publishers.

    Google Scholar 

  • Falls, W.A. and Davis, M, (1995b) Lesions of the central nucleus of the amygdala block conditioned excitation, but not conditioned inhibition of fear as measured with the fear-potentiated startle effect. Behav Neurosci 109: 379–387.

    Article  PubMed  CAS  Google Scholar 

  • Falls, W.A. and Davis, M.J. (1997) Inhibition of fear-potentiated startle can be detected after the offset of a feature trained in a serial feature negative discrimination. Journal of Experimental Psychology: Animal Behavioral Processes 23: 3–14.

    Google Scholar 

  • Falls, W.A., Josselyn, S.A., Gewirtz, J.C., Pistell, P., and Davis, M. (1998) The nucleus accumbens if not critical for condtioned inhibition of fear as measured with fear-potentiated startle. Soc Neurosci Abst 28:

    Google Scholar 

  • Falls, W.A., Miserendino, M.J.D., and Davis, M. (1992) Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J Neurosci 12: 854–863.

    PubMed  CAS  Google Scholar 

  • Falls, W.F. and Davis, M. (1994) Visual cortex ablations do not prevent extinction of fear-potentiated startle using a visual conditioned stimulus. Behav Neural Bio160: 259–270.

    Google Scholar 

  • Fanselow, M.S. (1986a) Associative vs. topographical accounts of the immediate shock freezing deficit in rats: Implications for the response selection rules governing species-specific defensive reactions. Learn and Motiv 17: 16–39.

    Google Scholar 

  • Fanselow, M.S. (1986b) Conditioned fear-induced analgesia: A competing motivational state theory of stress-analgesia. Annuals of the New York Academy of Science 467: 40–54.

    Google Scholar 

  • Fanselow, M.S. (1991) The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In: A. Depaulis and Bandler R., eds. The Midbrain Periaqueductal Gray Matter: Functional, Anatomical and Neurochemical Organization. New York: Plenum Publishing Co.

    Google Scholar 

  • Fendt, M. (1998) Different regions of the periaqueductal grey are involved differently in the expression and conditioned inhibition of fear-potentiated startle. European Journal of Neuroscience 10: 387684.

    Google Scholar 

  • Fendt, M., Koch, M., Schnitzler, H.-U. (1996) Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm. Behavioural Brain Research 74: 127–134.

    Article  PubMed  CAS  Google Scholar 

  • Fox, G.D. and Holland, P.C. (1998) Neurotoxic hippocampal lesions fail to impair reinstatement of an appetitively conditioned response. Behav Neurosci 112: 255–260.

    Article  PubMed  CAS  Google Scholar 

  • Frohardt, R., Guarraci, F.A., Bouton, M.E. (1999) The effects of neurotoxic hippocampal lesions on two effects of context following fear extinction. Behav Neurosci In press:.

    Google Scholar 

  • Gewirtz, J. and Davis, M. (1997) Second order fear conditioning prevented by blocking NMDA receptors in the amygdala. Nature 388: 471–474.

    Article  PubMed  CAS  Google Scholar 

  • Gewirtz, J.C., Falls, W.A., Davis, M. (1997) Normal conditioned inhibition and extinction of freezing and fear potentiated startle following electrolytic lesions of medial prefrontal cortex. Behav Neurosci 111: 712–726.

    Article  PubMed  CAS  Google Scholar 

  • Good, M., deHoz, L., Morris, R.G.M. (1998) Contingent versus incidental context processing during conditioning: Dissociation after excitotoxic hippocampal plus dentate gyrus lesions. Hippocampus 8: 147–159.

    Google Scholar 

  • Graeff, F.G., Silveira, M.C.L., Nogueira, R.L., Audi, E.A., Oliveira, R.M.W. (1993) Role of the amygdala and periaqueductal gray in anxiety and panic. Behav Brain Res 58: 123–131.

    Article  PubMed  CAS  Google Scholar 

  • Guarraci, F.A. and Frohardt, R.J. (1999) Amygdaloid D1 dopamine receptor involvement in Pavlovian fear conditioning. Brain Res 827: 28–40.

    Article  PubMed  CAS  Google Scholar 

  • Harris, J.A. and Westbrook, R.F. (1998a) Benzodiazepine-induced amnesia in rats: reinstatement of conditioned performance by noxious stimulation on test. Behav Neurosci 112: 183–192.

    Article  PubMed  CAS  Google Scholar 

  • Harris, J.A. and Westbrook, R.F. (1998b) Evidence that GABA transmission mediates context-specific extinction of learned fear. Psychopharmacology 140: 105–115.

    Article  PubMed  CAS  Google Scholar 

  • Harris, J.A. and Westbrook, R.F. (1999) The benzodiazepine midazolam does not impair Pavlovian fear conditioning but regulates when and where fear is expressed. Journal of experimental psychology: Animal behavioral processes 25: 236–246.

    Google Scholar 

  • Hearst, E. (1972) Some persistent problems in the analysis of conditioned inhibition. In: R. A. Boakes and Halliday M. S., eds. Inhibition and Learning. New York: Academic Press.

    Google Scholar 

  • Heldt, S.A. and Falls, W.A. (1998) Destruction of the auditory thalamus disrupts the production of fear but not the inhibition of fear conditioned to an auditory stimulus. Brain Res 813: 274–282.

    Article  PubMed  CAS  Google Scholar 

  • Helmstetter, F.J. (1992) The amygdala is essential for the expression of conditioned hypoalgesia. Behav Neurosci 106: 518–528.

    Article  PubMed  CAS  Google Scholar 

  • Helmstetter, F.J. and Tershner,S.A. (1994) Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses. The Journal of Neuroscience 14: 7099–7108.

    PubMed  CAS  Google Scholar 

  • Holland, P.C. (1985) The nature of conditioned inhibition in serial and simultaneous feature negative discriminations. In: R. R. Miller and Spear N. E., eds. Information Processing in Animals: Conditioned Inhibition. Hillsdale, N.J.: Lawrence Erlbaum Associates.

    Google Scholar 

  • Holland, P.C., Lamoureux, J.A., Han, J.-S., Gallagher, M. (1999) Hippocampal lesions interfere with Pavlovian negative ossasion setting. Hippocampus 9: 143–157.

    Article  PubMed  CAS  Google Scholar 

  • Holt, W. and Maren, S. (1999) Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory. J Neurosci 19: 9054–9062.

    PubMed  CAS  Google Scholar 

  • Honey, R.C. and Good, M. (1993) Selective hippocampal lesions abolish the context specificity of latent inhibition and conditioning. Behav Neurosci 107: 23–33.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, E.J., Macrae, M., Hutchinson, C.L. (1996) MK-801 protects conditioned response from extinction in the rabbit nictitating membrane preparation. Psychobiology 24: 127–135.

    CAS  Google Scholar 

  • Kim, M. and Davis, M. (1993) Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training, but do not prevent re-acquisition. Behav Neurosci 107: 580–595.

    Article  PubMed  CAS  Google Scholar 

  • King, D., Zigmond, M.J., and Finlay, J.M. (1997) Effects of dopamine depletion in the medial prefrontal cortex on the stress-induced increase in extracellular dopamine in the nucleus accumbens core and shell. Neuroscience 77: 141–153.

    Article  PubMed  CAS  Google Scholar 

  • Konorski, J. (1948) Conditioned reflexes and neuronal organization. London: Cambridge University Press.

    Google Scholar 

  • Konorski, J. (1967) Integrative activity of the brain: An interdisciplinary approach. Chicago: The University of Chicago Press.

    Google Scholar 

  • Leaton, R.N. and Borszcz, G.S. (1990) Hippocampal lesions and temporally chained conditioned stimuli in a conditioned suppression paradigm. Psychobiology 18: 81–88.

    Google Scholar 

  • LeDoux, J.E., Romanski, L., Xagoraris, A. (1989) Indelibility of subcortical memories. J Cogn Neurosci 1: 238–243.

    Article  Google Scholar 

  • LeDoux, J.E., Sakaguchi, A., Iwata, J., Reis, D.J. (1986a) Interruption of projections from the medial geniculate body to an archi-neostriatal field disrupts the classical conditioning of emotional responses to acoustic stimuli. Neuroscience 17: 615–627.

    Article  PubMed  CAS  Google Scholar 

  • LeDoux, J.E., Sakaguchi, A., Reis, D.J. (1986) Interuption of projections from the medial geniculate mediate emotional responses conditioned to acoustic stimuli. J Neurosci 17: 615–627.

    Article  CAS  Google Scholar 

  • Lee, H. and Kim, J. (1998) Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. Journal otNeuroscience 18: 8444–8454.

    CAS  Google Scholar 

  • Linke, R., De Lima, A.D., Schwegler, H., Pape, H.C. (1999) Direct synaptic connections of axons from superior colliculus with identified thalamo-amygadloid projection neurons in the rat: Possible substrates of a subcortical visual pathway to the amygdala. The Journal of Comparative Neurology 403: 158–170.

    Google Scholar 

  • Lovibond, P.F., Preston, G.C., and Mackintosh, N.J. (1984) Context specificity of conditioning, extinction and latent inhibition. Journal of Experimental Psychology: Animal Behavioral Processes 10: 360–375.

    Google Scholar 

  • Lubow, R.E. (1989) Latent inhibition and conditioned attention theory. New York: Cambridge University Press.

    Book  Google Scholar 

  • Mackintosh, N.J. (1974) The psychology of animal learning. New York: Academic Press.

    Google Scholar 

  • McAllister, W.R. and McAllister, D.E. (1971) Behavioral measurement of conditioned fear. In: F. R. Brush, ed Aversive Conditioning and Learning. New York: Academic Press.

    Google Scholar 

  • McGaugh,J., Cahill, L., Parent, M.B., Mesches, M.H., Coleman-Mesches, K., Salinas, J.A. (1995) Involvement of the amygdala in the regulation of memory storage. In: J. McGaugh, BermudezRattoni F. and Praco-Alcala R. A., eds. Plasticity in the Central Nervous System. Hillsdale, NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • McGaugh, J.L., Castellano, C., and Brioni, J. (1990) Picrotoxin enhances latent extinction of conditioned fear. Behvioral Neuroscience 104: 264–267.

    Article  CAS  Google Scholar 

  • McIntosh, A.R. and Gonzalez-Lima, F. (1995) Functional network interactions between parallel auditory pathways during Pavlovian conditioned inhibition. Brain Res 683: 228–241.

    Article  PubMed  CAS  Google Scholar 

  • McNish, K.A., Gewirtz, J.C. and Davis, M. (1997) Evidence of contextual fear conditioning following lesions of the hippocampus: A disruption of freezing but not fear-potentiated startle. J Neurosci 17: 9353–9360.

    Google Scholar 

  • Miserendino, M.J.D., Sananes,C.B., Melia, K.R., Davis, M. (1990) Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345: 716–718.

    PubMed  CAS  Google Scholar 

  • Morgan, M.A. and LeDoux, J.E. (1995) Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci 109: 681–688.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, M.A. and LeDoux, J.E. (1996) Medial prefrontal cortex (mPFC) and the extinction of fear: Differential effecs of pre-or post-training lesions. Soc Neurosci Abst 22: 1116.

    Google Scholar 

  • Morgan, M.A. and LeDoux JE (1999) Contribution of ventrolateral prefrontal cortex to the acquistion and extinction of conditioned fear in rats. Neurobiol Learn Memory 72: 244–251.

    Article  CAS  Google Scholar 

  • Morgan, M.A., Romanski, L.M., LeDoux, J.E. (1993) Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci Letts 163: 109–113.

    Article  CAS  Google Scholar 

  • Morrow, B.A., Elsworth, J.D., Inglis, F.M., Roth, R.H. (1999a) An antisense oligonucleotide reverses the footshock-induced expression of Fos in the rat medial prefrontal cortex and the subsequent expression of conditioned fear-induced immobility. J Neurosci 19: 5666–5673.

    PubMed  CAS  Google Scholar 

  • Morrow, B.A., Elsworth, J.D., Rasmusson, A.M., Roth, R.H. (1999b) The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 92: 553–564.

    Article  PubMed  CAS  Google Scholar 

  • Nader, K. and LeDoux, J.E. (1999) Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations. Behav Neurosci 113: 891–901.

    Article  PubMed  CAS  Google Scholar 

  • Papini, M.R. and Bitterman, M.E. (1993) The two-test strategy in the study of inhibitory conditioning. Journal of Experimental Psychology: Animal Behavior Processes 19: 342–352.

    Google Scholar 

  • Pavlov, I.P. (1927) Conditioned Reflexes. Oxford University Press: Oxford University Press.

    Google Scholar 

  • Quirk, G.J., Kohanski, G.J., Ayala, O. (1998) Lesions of medial prefrontal cortex retard extinction of fear conditioning between sessions, but not within a session. Soc Neurosci Abst 28: 1683.

    Google Scholar 

  • Quirk, G.J., Rosaly, E., Romero, R.V., Santini, E., Muller, R.U. (1999) NMDA receptors are required for long-term but not short-term memory of extinction learning. Soc Neurosci Abst 25: 1620.

    Google Scholar 

  • Reiss, S. and Wagner, A.R. (1972) CS habituation produces a “latent inhibition effect” but no active “conditioned inhibition.” Learning Motivation 3: 237–245.

    Google Scholar 

  • Rescorla, R.A. (1969) Pavlovian conditioned inhibition. Psychological Bulletin 72: 77–94.

    Article  Google Scholar 

  • Rescorla, R.A. and Heth, C.D. (1975) Reinstatement of fear to an extinguished conditioned stimulus. Journal of Experimental Psychlogy: Animal Behavior Processes 1: 88–96.

    Google Scholar 

  • Robinson, G.B., Port, R.L., Stillwell, E.J. (1993) Latent inhibition of the classically conditioned rabbit nictitating membrane response is unaffected by the NMDA antagonist MK801. Psychobiology: 120124.

    Google Scholar 

  • Schmaltz, L.W. and Theiosus, J. (1972) Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits (oryctolagus cuniculus). J Comp Physiol Psychol 79: 328–333.

    Article  PubMed  CAS  Google Scholar 

  • Skinner, B. F. (1950) Are theories of learning necessary? Psychology Review 57: 193–216.

    Article  CAS  Google Scholar 

  • Skinner, B.F. (1938) Behavior of Organisms. New York: Appleton-Century-Crofts.

    Google Scholar 

  • Solomon, P.R. (1977) Role of hippocampus in blocking and conditioned inhibition of the rabbit’s nictitating membrane response. Journal of Comparative Physiological Psychiatry 91: 407–417.

    Article  CAS  Google Scholar 

  • Taylor, J.R. and Robbins, T.W. (1984) Enhanced behavioral control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology 84: 405–412.

    Article  PubMed  CAS  Google Scholar 

  • Teich, A.H., McCabe, P.M., Gentile, C.C., Schneiderman, L.S., Winters, R.W., Liskosky, D.R., Schneiderman, N. (1989) Auditory cortex lesions prevent the extinction of heart rate conditioning to tonal stimuli in rabbits. Brain Res 480: 210–218.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, E., Yadin, E., Strickland, C.E. (1991) Septal unit activity during classical conditioning: A regional comparison. Brain Res 547: 303–308.

    Google Scholar 

  • Walker, D.L., Cassella, J.V., Lee, Y., de Lima, T.C.M., Davis, M. (1997) Opposing roles of the amygdala and dorsolateral periaqueductal gray in fear-potentiated startle. Brain Res Bull 111: 692702.

    Google Scholar 

  • Williams, D.A., Overmier, J.B., LoLordo, V.M. (1992) A reevaluation of Rescorla’s early dictums about Pavlovian Conditioned Inhibition. Psychological Bulletin 111: 275–290.

    Article  Google Scholar 

  • Willick, M.L. and Kokkinides, L. (1995) Cocaine enhances the expression of fear-potentiated startle: Evaluation of state-dependent extinction and the shock-sensitization of acoustic startle. Behav Neurosci 109: 929–938.

    Google Scholar 

  • Wilson, A., Brooks, D., and Bouton, M.E. (1995) The role of the rat hippocampal system in several effects of context extincition. Behav Neurosci 109: 828–836.

    Article  PubMed  CAS  Google Scholar 

  • Yadin, E. (1989) Unit activity in the medial septum during differential appetitive conditioning. Behavioural Brain Research 33: 45–50.

    Article  PubMed  CAS  Google Scholar 

  • Yadin, E. and Thomas, E. (1981) Septal correlates of conditioned inhibition. J Comp Physiol Psycho) 95: 331–340.

    Article  CAS  Google Scholar 

  • Yadin, E. and Thomas, E. (1996) Stimulation of the lateral septum attenuates immobilization-induced stress ulcers. Physiol Behav 59: 883–886.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Michael Davis
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  2. William A. Falls
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  3. Jonathan Gewirtz
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Editors and Affiliations

  1. Psychobiology Research Unit, Department of Psychology, Tel Aviv University, 69978, Tel-Aviv, Israel

    Michael S. Myslobodsky

  2. Howard University, USA

    Michael S. Myslobodsky

  3. Department of Psychology, Tel Aviv University, 69978, Tel-Aviv, Israel

    Ina Weiner

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Davis, M., Falls, W.A., Gewirtz, J. (2000). Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition. In: Myslobodsky, M.S., Weiner, I. (eds) Contemporary Issues in Modeling Psychopathology. Neurobiological Foundation of Aberrant Behaviors, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4860-4_8

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